Macrocyclic 14-Membered Ring Diketal Diamines: Synthesis, Conformational Analysis and99mTc Radiolabeling Evaluation
نویسندگان
چکیده
منابع مشابه
Bis-14-membered ring diketal diamines: synthesis and evaluation of their anti-HIV and anti-tumoral activities.
Chiral and achiral macrocyclic bis-diketal diamines, analogs of bicyclam AMD 3100, were synthesized in three steps from the previously obtained 14-membered ring diketal dilactams. Their monoreduction with lithium aluminium hydride gave the corresponding diketal aminolactams. Coupling these with dibromo-p-xylene led to xylyl dimer compounds. A second reduction step yielded the expected bis-diket...
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Schiff base condensation of benzil bis(hydrazone) with formaldehyde, acetone and benzaldehyde and its nickel(II) complexes were synthesised. Preparation of the free ligands was accomplished by refluxing benzil with hydrazine derivatives in 1:10 mole ratios in ethylene glycol. The spectral characterisation of hydrazone based 14-membered octaaza macrocyclic complexes of nickel(II) was undertaken....
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[reaction: see text] A novel ring opening ring closing metathesis (ROM-RCM) was demonstrated for cyclic conjugated dienes, effecting the excision of a C(2)H(2) unit and a net ring contraction. Applying the ring contraction metathesis, new 14-membered ring macrolide antibiotics were synthesized in a single step from existing 16-membered ring macrolides. This new class of macrolide antibiotics wi...
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Three types of small ring compounds (epoxides, aziridines and cyclopropanes) can be synthesized stereoselectively via ylide route. Among them, the stereochemistry of vinyloxiranes, vinylaziridines, cyclopropylesters, amides and ketones can be tuned by the choice of reaction conditions and ylides with varying heteroatoms and ligands. Optically active epoxides and acetylenylaziridines can be prep...
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2008
ISSN: 1434-193X,1099-0690
DOI: 10.1002/ejoc.200701151